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KMID : 0357920090430030279
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Korean Journal of Pathology
2009 Volume.43 No. 3 p.279 ~ p.284
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The Cytologic Features of Desmoplastic Small Round Cell Tumor with Intranuclear Inclusions - A Case Report -
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Lee Ho-Chang
Han Hye-Sook
Lee Ok-Jun
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Abstract
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Desmoplastic small round cell tumor (DSRCT) is a rare neoplasm of young adults and it is characterized by polyphenotypic differentiation. We experienced a case of abdominal DSRCT that occurred in a 19-year-old female who presented with painful swelling of her right forearm. The tumor was cytokeratin-negative and it exhibited some tumor cells with intranuclear inclusions. Molecular demonstration of EWS-WT1 fusion transcripts is particularly useful to confirm the diagnosis of DSRCT without epithelial differentiation. We report here on a case of cytokeratin-negative DSRCT that showed an unusual feature of intranuclear inclusions.
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KEYWORD
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Desmoplastic small round cell tumor, Cytokeratin, EWS-WT1 fusion protein, Intranuclear Inclusions, Cytology
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